山田 源 業績リスト

2015年

Harada M, Omori A, Nakahara C, Nakagata N, Akita K and *Yamada G.
Tissue-specific roles of FGF signaling in external genitalia development.
Dev Dyn, Doi.24277, 2015
Okazawa M, Murashima A, Harada M, Nakagata N, Noguchi M, Morimoto M, Kimura T, Ornitz D and Yamada G.
Region-specific regulation of cell proliferation by Fgf receptor signaling during the Wolffian duct development.
Dev Biol, 400, 139-147, 2015
Miyagawa S, Sato M, Sudo T, Yamada G and Iguchi T.
Unique Roles of Estrogen-Dependent Pten Control in Epithelial Cell Homeostasis of Mouse Vagina.
Oncogene, 34, 1035-1043, 2015

2014年

Ipulan LA, Suzuki K, Sakamoto Y, Murashima A, Imai Y, Omori A, Nakagata N, Nishinakamura R, Valasek P and Yamada G.
Non-myocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle.
Endocrinology, 2014 (in press)
Miyagawa S, Sato M, Sudo T, Yamada G and Iguchi T.
Unique Roles of Estrogen-Dependent Pten Control in Epithelial Cell Homeostasis of Mouse Vagina.
Oncogene, 155, 2467-2479, 2014
Suzuki K, Numata T, Suzuki H, Raga DD, Ipulana L, Yokoyama C, Matsushita S, Hamada M, Nakagata N, Nishinakamura R, Kume S, Takahashi S and Yamada G.
Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation.
PNAS, 111, 16407-16412, 2014 (doi: 10.1073/pnas.1413273111.)
Murashima A, Kishigami S, Thomson A and Yamada G.
Androgens and mammalian male reproductive tract development.
Biochimica et Biophysica Acta, pii: S1874-9399, 00126-6, 2014 (doi: 10.1016/j.bbagrm.2014.05.020.)
Omori A, Miyagawa S, Ogino Y, Harada M, Ishii K, Sugimura Y, Ogino H, Nakagata N and Yamada G.
Essential roles of epithelial bone morphogenetic protein signaling during prostatic development.
Endocrinology, 155, 2534-2544, 2014
Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC and Yamada G.
Disruption of the Temporally Regulated Cloaca Endodermal β-catenin Signaling Causes Anorectal Malformations.
Cell Death Differentiation, 21, 990-997, 2014
Ng RC, Matsumaru D, Ho A, Garcia-Barcelo MM, Yuan ZW, Smith D, Kodjabachian L, Tam P, Yamada G and Lui VC.
Dysregulation of Wnt Inhibitory Factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations.
Cell Death Differentiation, 21, 978-989, 2014
Ipulan LA, Suzuki K, Matsushita S, Suzuki H, Okazawa M, Jacinto S, Hirai S and Yamada G.
Development of the External Genitalia and its Sexual Dimorphic Regulation.
Sexual Development, 8, 297-310, 2014

2013年

Murashima A, Akita H, Okazawa M, Kishigami S, Nakagata N, Nishinakamura R and Yamada G.
Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm.
Dev Biol, 386, 216-226, 2013
Ogino Y, Hirakawa I, Inohaya K, Sumiya E, Yamada G and Iguchi T.
Bmp7 and Lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in medaka.
Endocrinology, 155, 449-462, 2013
Matsumaru D, Haraguchi R, Anne M. Moon, Satoh Y, Nakagata N, Yamamura K, Takahashi N, Kitazawa S and Yamada G.
Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation.
Eur J Hum Genet, 22, 350-357, 2013
Semba K, Araki K, Matsumoto K, Suda H, Ando T, Sei A, Mizuta H, Takagi K, Nakahara M, Muta M, Yamada G, Nakagata N, Iida A, Ikegawa S, Nakamura Y, Araki M, Abe K and Yamamura K.
Ectopic Expression of Ptf1a Induces Spinal Defects, Urogenital Defects, and Anorectal Malformations in Danforth's Short Tail Mice
PLoS Genet, 9, e1003204. doi:10.1371/journal.pgen.1003204, 2013
*Villacorte M, *Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N and Yamada G.
Beta-catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation.
Oncogene, 32, 3477-3482, 2013
(*equaly contributed first author)
業績トピックス

2012年

Suzuki K, Adachi Y, Numata T, Nakada S, Yanagita M, Nakagata N, Evans M.S., Graf D, Economides A, Haraguchi R, Moon M.A. and Yamada G.
Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.
PLoS ONE, 7(9):e43453. doi: 10.1371/journal.pone.0043453, 2012
*Haraguchi R, *Matsumaru D, Nakagata N, Miyagawa S, Suzuki K, Kitazawa S and Yamada G.
The Hedgehog Signal Induced Modulation of Bone Morphogenetic Protein Signaling: An Essential Signaling Relay for Urinary Tract Morphogenesis.
PLoS ONE, 7(7):e42245. doi: 10.1371/journal.pone.0042245, 2012
(*equaly contributed first author)
Yamaguchi M, Ohba T, Tashiro H, Yamada G and Katabuchi H.
Human chorionic gonadotropin induces human macrophages to form intracytoplasmic vacuoles mimicking Hofbauer cells in human chorionic villi.
CELLS TISSUES ORGANS, 197, 127-135, 2012
Mazahery A, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Behringer R and *Yamada G.
Functional analysis of ectodermal β-catenin during external genitalia formation.
Congenital Anomalies, 53, 34-41, 2012
Okano J, Kimura W, Virginia E. Papaionnou, Miura N, Yamada G, Shiota K and Sakai Y.
The Regulation of Endogenous Retinoic Acid Level Through CYP26B1 Is Required for Elevation of Palatal Shelves.
DEV DYN 241, 1744-1756, 2012

2011年

Ohta S, Yukiko O, Suzuki K, Kamimura M, Tachibana K and Yamada G.
Sonoporation for gene transfer into embryos.
Cold Spring Harb Protoc., 3, prot5581, 2011
Miyagawa S, Matsumaru D, Murashima A, Omori A. Satoh Y. Haraguchi R. Motoyama J. Iguchi T. Nakagata N. Chi-chung Hui and Yamada G.
The role of Sonic hedgehog-Gli2 pathway in the masculinization of external genitalia.
Endocrinology, 152, 2894-903, 2011
Ogino, Y., Miyagawa, S., Katoh, H., Prins, G. S., Iguchi, T. and Yamada, G.
Essential functions of androgen signaling emerged through the developmental analysis of vertebrate sex characteristics.
Evol. Dev., 13, 315-325, 2011 (review)
Omori A., Harada M., Ohta S., Villacorte M., Sugimura Y., Shiraishi T., Suzuki K., Nakagata N., Ito T. and Yamada G.
Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development : A mouse model for congenital cystic dilation.
Congenit Anom., 51, 102-109, 2011 (review)
Liu L., Suzuki K., Nakagata N., Mihara K., Matsumaru D., Ogino Y., Yashiro Y., Hamada H., Liu X., Evans S., Mendelsohn C. and Yamada G.
Retinoic acid signaling regulates Sonic hedgehog and Bone morphogenetic protein signalings during genital tubercle development.
Birth Defects Res B Dev Reprod Toxicol, doi:10.1002 bdrb.20344, 2011
Kim-Kaneyama JR., Takeda N., Sasai A., Miyazaki A., Sata M., Hirabayashi T., Shibanuma M., Yamada G. and Nose K.
Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling.
J Mol Cell Cardiol., 50, 77-86, 2011
Matsumaru D., Haraguchi R., Miyagawa S., Motoyama J., Nakagata N., Meijlink F. and Yamada G.
Genetic Analysis of Hedgehog Signaling in Ventral Body Wall Development and the Onset of Omphalocele Formation.
PLoS ONE, 20, e16260, 2011
Murashima A., Miyagawa S., Ogino Y., Nishida-Fukuda H., Araki K., Matsumoto T., Kaneko T., Yoshinaga K., Yamamura K., Kurita T., Kato S., Moon M.A. and Yamada, G.
Essential Roles of Androgen Signaling in Wolffian Duct Stabilization and Epididymal Cell Differentiation.
Endocrinology, 152, 1640-1651 2011 (Faculty of 1000 Medicine 掲載)
日本語総説
村嶋亜紀、宮川信一、荻野由紀子、中潟直己、山田源
アンドロゲンシグナルの性差構築機構:器官形成における性差発現の新次元
「Molecular Mechanisms of Androgen Signaling: New Insight for Sexual Differentiation in Organ Development」
細胞工学, 30, 856-862, 2011
鈴木堅太郎、山田源
外生殖器の発生分化と異常のモデル
完全版マウス・ラット疾患モデル活用ハンドブック, 394-40, 2011

2010年

Villacorte M, Suzuki K, Hayashi K, Chuva de Sousa-Lopes S, Haraguchi R., Taketo MM, Nakagata N and Yamada G.
Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation.
Biochem Biophys Res Commun., 391, 1653-1657, 2010
Imamura Y, Ishikawa S, Sato N, Karashima R, Hiyoshi Y, Nagai Y, Koga Y, Hayashi N, Watanabe M, Yamada G and Baba H.
Adenoviral oncolytic suicide gene therapy for a peritoneal dissemination model of gastric cancer in mice.
Ann Surg Oncol., 17, 643-652, 2010
Ohta S, Schoenwolf GC and Yamada G.
The cessation of gastrulation BMP signaling and EMT during and at the end of gastrulation.
Cell Adhesion and Migraton, 4,1-7, 2010
Fukami M, Nagai T, Mochizuki H, Muroya K, Yamada G, Takitani K and Ogata T.
Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency.
Mol Genet Metab., 100, 269-273, 2010
日本語総説
原田理代、山田源
外生殖器・内生殖器 発生過程におけるWntシグナルの役割
医学の歩み vol.233 No.10 1008-1014,2010
宮川信一、原田理代、原口竜摩、鈴木堅太郎、中原千彰、松丸大輔、金子武人、中潟直己、山田源
Wnt, FGFの三大増殖因子の相互作用:器官が伸長する(大きくなる)ためにどのようなリレーが必要か細胞工学
細胞工学 vol.29 No.2 144, 2010
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